Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells

• Eveline A. I. F. Queiroz,

  Affiliations Pharmacology Department, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil, Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil

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• Stephanie Puukila,

  Affiliation Biology Department, Lakehead University, Thunder Bay, Ontario, Canada

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• Rosangela Eichler,

  Affiliation Pharmacology Department, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil

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• Sandra C. Sampaio,

  Affiliation Pharmacology Department, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil

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• Heidi L. Forsyth,

  Affiliation Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada

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• Simon J. Lees,

  Affiliations Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada, Biology Department, Lakehead University, Thunder Bay, Ontario, Canada

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• Aneli M. Barbosa,

  Affiliation Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada

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• Robert F. H. Dekker,

  Affiliation Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada

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• Zuleica B. Fortes ,

  * E-mail: zbfortes@icb.usp.br (ZBF); nkhaper@nosm.ca (NK)

  Affiliation Pharmacology Department, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil

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• Neelam Khaper

  * E-mail: zbfortes@icb.usp.br (ZBF); nkhaper@nosm.ca (NK)

  Affiliations Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada, Biology Department, Lakehead University, Thunder Bay, Ontario, Canada

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