C-Reactive Protein Inhibits Survivin Expression via Akt/mTOR Pathway Downregulation by PTEN Expression in Cardiac Myocytes

Beom Seob Lee; Soo Hyuk Kim; Jaewon Oh; Taewon Jin; Eun Young Choi; Sungha Park; Sang-Hak Lee; Ji Hyung Chung; Seok-Min Kang

doi:10.1371/journal.pone.0098113

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Peer-reviewed

Research Article

C-Reactive Protein Inhibits Survivin Expression via Akt/mTOR Pathway Downregulation by PTEN Expression in Cardiac Myocytes

Beom Seob Lee,

Affiliations Graduate Program in Science for Aging, Yonsei University, Seoul, Republic of Korea, Cardiology Division, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea, Severance Integrative Research Institute for Cerebral and Cardiovascular Diseases (SIRIC), Yonsei University Health System, Seoul, Republic of Korea
⨯
Soo Hyuk Kim,

Affiliations Graduate Program in Science for Aging, Yonsei University, Seoul, Republic of Korea, Department of Applied Bioscience, College of Life Science, CHA University, Gyeonggi-do, Republic of Korea
⨯
Jaewon Oh,

Affiliation Cardiology Division, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
⨯
Taewon Jin,

Affiliations Graduate Program in Science for Aging, Yonsei University, Seoul, Republic of Korea, Department of Applied Bioscience, College of Life Science, CHA University, Gyeonggi-do, Republic of Korea
⨯
Eun Young Choi,

Affiliations Graduate Program in Science for Aging, Yonsei University, Seoul, Republic of Korea, Department of Applied Bioscience, College of Life Science, CHA University, Gyeonggi-do, Republic of Korea
⨯
Sungha Park,

Affiliation Cardiology Division, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
⨯
Sang-Hak Lee,

Affiliation Cardiology Division, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
⨯
Ji Hyung Chung ,

* E-mail: jhchung@cha.ac.kr (JHC); smkang@yuhs.ac (SMK)

Affiliation Department of Applied Bioscience, College of Life Science, CHA University, Gyeonggi-do, Republic of Korea
⨯
Seok-Min Kang

* E-mail: jhchung@cha.ac.kr (JHC); smkang@yuhs.ac (SMK)

Affiliations Cardiology Division, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea, Severance Integrative Research Institute for Cerebral and Cardiovascular Diseases (SIRIC), Yonsei University Health System, Seoul, Republic of Korea, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
⨯

C-Reactive Protein Inhibits Survivin Expression via Akt/mTOR Pathway Downregulation by PTEN Expression in Cardiac Myocytes

Beom Seob Lee,
Soo Hyuk Kim,
Jaewon Oh,
Taewon Jin,
Eun Young Choi,
Sungha Park,
Sang-Hak Lee,
Ji Hyung Chung,
Seok-Min Kang

Published: May 27, 2014
https://doi.org/10.1371/journal.pone.0098113

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C-reactive proteins
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Muscle cells
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Small interfering RNA
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Immunoblotting
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Apoptosis
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Cell cycle and cell division
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Protein expression
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Reverse transcriptase-polymerase chain reaction
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