Oral and Vaginal Epithelial Cell Lines Bind and Transfer Cell-Free Infectious HIV-1 to Permissive Cells but Are Not Productively Infected

Arinder Kohli; Ayesha Islam; David L. Moyes; Celia Murciano; Chengguo Shen; Stephen J. Challacombe; Julian R. Naglik

doi:10.1371/journal.pone.0098077

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Open Access

Peer-reviewed

Research Article

Oral and Vaginal Epithelial Cell Lines Bind and Transfer Cell-Free Infectious HIV-1 to Permissive Cells but Are Not Productively Infected

Arinder Kohli ,

Contributed equally to this work with: Arinder Kohli, Ayesha Islam

Affiliation Department of Oral Immunology, Clinical and Diagnostic Sciences, King's College London Dental Institute, King's College London, London, United Kingdom
⨯
Ayesha Islam ,

Contributed equally to this work with: Arinder Kohli, Ayesha Islam

Affiliations Department of Oral Immunology, Clinical and Diagnostic Sciences, King's College London Dental Institute, King's College London, London, United Kingdom, Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
David L. Moyes,

Affiliation Department of Oral Immunology, Clinical and Diagnostic Sciences, King's College London Dental Institute, King's College London, London, United Kingdom
⨯
Celia Murciano,

Affiliations Department of Oral Immunology, Clinical and Diagnostic Sciences, King's College London Dental Institute, King's College London, London, United Kingdom, Department of Microbiology and Ecology, University of Valencia, Valencia, Spain
⨯
Chengguo Shen,

Affiliation Department of Oral Immunology, Clinical and Diagnostic Sciences, King's College London Dental Institute, King's College London, London, United Kingdom
⨯
Stephen J. Challacombe,

Affiliation Department of Oral Immunology, Clinical and Diagnostic Sciences, King's College London Dental Institute, King's College London, London, United Kingdom
⨯
Julian R. Naglik

* E-mail: julian.naglik@kcl.ac.uk

Affiliation Department of Oral Immunology, Clinical and Diagnostic Sciences, King's College London Dental Institute, King's College London, London, United Kingdom
⨯

Oral and Vaginal Epithelial Cell Lines Bind and Transfer Cell-Free Infectious HIV-1 to Permissive Cells but Are Not Productively Infected

Arinder Kohli,
Ayesha Islam,
David L. Moyes,
Celia Murciano,
Chengguo Shen,
Stephen J. Challacombe,
Julian R. Naglik

Published: May 23, 2014
https://doi.org/10.1371/journal.pone.0098077

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HIV-1
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Epithelial cells
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Cell binding
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Flow cytometry
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Polymerase chain reaction
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Epithelium
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Viral transmission and infection
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Serine proteases
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