MicroRNA-146a Regulates Human Foetal Femur Derived Skeletal Stem Cell Differentiation by Down-Regulating SMAD2 and SMAD3

Kelvin S. C. Cheung; Nunzia Sposito; Patrick S. Stumpf; David I. Wilson; Tilman Sanchez-Elsner; Richard O. C. Oreffo

doi:10.1371/journal.pone.0098063

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Peer-reviewed

Research Article

MicroRNA-146a Regulates Human Foetal Femur Derived Skeletal Stem Cell Differentiation by Down-Regulating SMAD2 and SMAD3

Kelvin S. C. Cheung,

Affiliations Bone and Joint Research Group, Institute of Developmental Sciences, Southampton General Hospital, Southampton, United Kingdom, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, University of Southampton, Southampton, United Kingdom
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Nunzia Sposito,

Affiliations Bone and Joint Research Group, Institute of Developmental Sciences, Southampton General Hospital, Southampton, United Kingdom, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, University of Southampton, Southampton, United Kingdom
⨯
Patrick S. Stumpf,

Affiliations Bone and Joint Research Group, Institute of Developmental Sciences, Southampton General Hospital, Southampton, United Kingdom, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, University of Southampton, Southampton, United Kingdom
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David I. Wilson,

Affiliation Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, University of Southampton, Southampton, United Kingdom
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Tilman Sanchez-Elsner,

Affiliation Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom
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Richard O. C. Oreffo

* E-mail: richard.oreffo@soton.ac.uk

Affiliations Bone and Joint Research Group, Institute of Developmental Sciences, Southampton General Hospital, Southampton, United Kingdom, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, University of Southampton, Southampton, United Kingdom
⨯

MicroRNA-146a Regulates Human Foetal Femur Derived Skeletal Stem Cell Differentiation by Down-Regulating SMAD2 and SMAD3

Kelvin S. C. Cheung,
Nunzia Sposito,
Patrick S. Stumpf,
David I. Wilson,
Tilman Sanchez-Elsner,
Richard O. C. Oreffo

Published: June 3, 2014
https://doi.org/10.1371/journal.pone.0098063

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Femur
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Cell differentiation
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Collagens
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Gene expression
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Hyperexpression techniques
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MicroRNAs
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SMAD signaling
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