Immunization of Rabbits with Highly Purified, Soluble, Trimeric Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Induces a Vigorous B Cell Response and Broadly Cross-Reactive Neutralization

Gerald V. Quinnan Jr; Olusegun Onabajo; Pengfei Zhang; Lianying Yan; Joseph J. Mattapallil; Zhiqiang Zhang; Ming Dong; Min Lu; David Montefiori; Celia LaBranche; Christopher C. Broder

doi:10.1371/journal.pone.0098060

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Peer-reviewed

Research Article

Immunization of Rabbits with Highly Purified, Soluble, Trimeric Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Induces a Vigorous B Cell Response and Broadly Cross-Reactive Neutralization

Gerald V. Quinnan Jr ,

* E-mail: gerald.quinnan@usuhs.edu

Affiliation Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Olusegun Onabajo,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Pengfei Zhang,

Affiliation Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Lianying Yan,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Joseph J. Mattapallil,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Zhiqiang Zhang,

Affiliation Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Ming Dong,

Affiliation Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Min Lu,

Affiliation Department of Microbiology and Molecular Genetics, Public Health Research Institute, New Jersey Medical School, Newark, New Jersey, United States of America
⨯
David Montefiori,

Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Celia LaBranche,

Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Christopher C. Broder

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯

Immunization of Rabbits with Highly Purified, Soluble, Trimeric Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Induces a Vigorous B Cell Response and Broadly Cross-Reactive Neutralization

Gerald V. Quinnan Jr,
Olusegun Onabajo,
Pengfei Zhang,
Lianying Yan,
Joseph J. Mattapallil,
Zhiqiang Zhang,
Ming Dong,
Min Lu,
David Montefiori,
Celia LaBranche

Published: May 20, 2014
https://doi.org/10.1371/journal.pone.0098060

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