Direct Lentiviral-Cyclooxygenase 2 Application to the Tendon-Bone Interface Promotes Osteointegration and Enhances Return of the Pull-Out Tensile Strength of the Tendon Graft in a Rat Model of Biceps Tenodesis

Charles H. Rundle; Shin-Tai Chen; Michael J. Coen; Jon E. Wergedal; Virginia Stiffel; Kin-Hing William Lau

doi:10.1371/journal.pone.0098004

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Direct Lentiviral-Cyclooxygenase 2 Application to the Tendon-Bone Interface Promotes Osteointegration and Enhances Return of the Pull-Out Tensile Strength of the Tendon Graft in a Rat Model of Biceps Tenodesis

Charles H. Rundle ,

Contributed equally to this work with: Charles H. Rundle, Shin-Tai Chen, Michael J. Coen

Affiliations Musculoskeletal Disease Center, J. L. Pettis Memorial VA Medical Center, Loma Linda, California, United States of America, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California, United State of America
⨯
Shin-Tai Chen ,

Contributed equally to this work with: Charles H. Rundle, Shin-Tai Chen, Michael J. Coen

Affiliations Musculoskeletal Disease Center, J. L. Pettis Memorial VA Medical Center, Loma Linda, California, United States of America, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California, United State of America, Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, California, United State of America
⨯
Michael J. Coen ,

Contributed equally to this work with: Charles H. Rundle, Shin-Tai Chen, Michael J. Coen

Affiliations Musculoskeletal Disease Center, J. L. Pettis Memorial VA Medical Center, Loma Linda, California, United States of America, Department of Orthopedic Surgery, Loma Linda University School of Medicine, Loma Linda, California, United State of America
⨯
Jon E. Wergedal,

Affiliations Musculoskeletal Disease Center, J. L. Pettis Memorial VA Medical Center, Loma Linda, California, United States of America, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California, United State of America, Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, California, United State of America
⨯
Virginia Stiffel,

Affiliation Musculoskeletal Disease Center, J. L. Pettis Memorial VA Medical Center, Loma Linda, California, United States of America
⨯
Kin-Hing William Lau

* E-mail: William.Lau@med.va.gov

Affiliations Musculoskeletal Disease Center, J. L. Pettis Memorial VA Medical Center, Loma Linda, California, United States of America, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California, United State of America, Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, California, United State of America
⨯

Direct Lentiviral-Cyclooxygenase 2 Application to the Tendon-Bone Interface Promotes Osteointegration and Enhances Return of the Pull-Out Tensile Strength of the Tendon Graft in a Rat Model of Biceps Tenodesis

Charles H. Rundle,
Shin-Tai Chen,
Michael J. Coen,
Jon E. Wergedal,
Virginia Stiffel,
Kin-Hing William Lau

Published: May 21, 2014
https://doi.org/10.1371/journal.pone.0098004

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