Knockout of Endothelial Cell-Derived Endothelin-1 Attenuates Skin Fibrosis but Accelerates Cutaneous Wound Healing

Katsunari Makino; Masatoshi Jinnin; Jun Aoi; Ikko Kajihara; Takamitsu Makino; Satoshi Fukushima; Keisuke Sakai; Kazuhiko Nakayama; Noriaki Emoto; Masashi Yanagisawa; Hironobu Ihn

doi:10.1371/journal.pone.0097972

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Open Access

Peer-reviewed

Research Article

Knockout of Endothelial Cell-Derived Endothelin-1 Attenuates Skin Fibrosis but Accelerates Cutaneous Wound Healing

Katsunari Makino ,

* E-mail: mjin@kumamoto-u.ac.jp

Affiliation Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Masatoshi Jinnin,

Affiliation Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Jun Aoi,

Affiliation Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Ikko Kajihara,

Affiliation Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Takamitsu Makino,

Affiliation Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Satoshi Fukushima,

Affiliation Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Keisuke Sakai,

Affiliation Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯
Kazuhiko Nakayama,

Affiliation Clinical Pharmacy, Kobe Pharmaceutical University, Kobe, Japan
⨯
Noriaki Emoto,

Affiliation Clinical Pharmacy, Kobe Pharmaceutical University, Kobe, Japan
⨯
Masashi Yanagisawa,

Affiliations Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, International Institute for Integrative Sleep Medicine (WPI-IIIS) and Center for Behavioral Molecular Genetics, University of Tsukuba, Tsukuba, Japan
⨯
Hironobu Ihn

Affiliation Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
⨯

Knockout of Endothelial Cell-Derived Endothelin-1 Attenuates Skin Fibrosis but Accelerates Cutaneous Wound Healing

Katsunari Makino,
Masatoshi Jinnin,
Jun Aoi,
Ikko Kajihara,
Takamitsu Makino,
Satoshi Fukushima,
Keisuke Sakai,
Kazuhiko Nakayama,
Noriaki Emoto,
Masashi Yanagisawa

Published: May 22, 2014
https://doi.org/10.1371/journal.pone.0097972

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