Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

Yolanda Williams-Bey; Cedric Boularan; Ali Vural; Ning-Na Huang; Il-Young Hwang; Chong Shan-Shi; John H. Kehrl

doi:10.1371/journal.pone.0097957

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Peer-reviewed

Research Article

Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

Yolanda Williams-Bey,

Affiliation B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Cedric Boularan,

Affiliation B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ali Vural,

Affiliation B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ning-Na Huang,

Affiliation B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Il-Young Hwang,

Affiliation B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Chong Shan-Shi,

Affiliation B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
John H. Kehrl

* E-mail: jkehrl@niaid.nih.gov

Affiliation B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

Yolanda Williams-Bey,
Cedric Boularan,
Ali Vural,
Ning-Na Huang,
Il-Young Hwang,
Chong Shan-Shi,
John H. Kehrl

Published: June 9, 2014
https://doi.org/10.1371/journal.pone.0097957

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Inflammasomes
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Macrophages
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Transcription factors
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Bioluminescence resonance energy transfer
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Autophagic cell death
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Secretion
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Transfection
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Fatty acids
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