Pemetrexed Induces S-Phase Arrest and Apoptosis via a Deregulated Activation of Akt Signaling Pathway

Kun-Chieh Chen; Tsung-Ying Yang; Chun-Chi Wu; Chi-Chih Cheng; Shih-Lan Hsu; Hsiao-Wen Hung; Jian-Wei Chen; Gee-Chen Chang

doi:10.1371/journal.pone.0097888

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Peer-reviewed

Research Article

Pemetrexed Induces S-Phase Arrest and Apoptosis via a Deregulated Activation of Akt Signaling Pathway

Kun-Chieh Chen,

Affiliations Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China, Institute of Biomedical Science, National Chung Hsing University, Taichung, Taiwan, Republic of China
⨯
Tsung-Ying Yang,

Affiliation Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
⨯
Chun-Chi Wu,

Affiliations Institute of Medicine, Chung Shang Medical University, Taichung, Taiwan, Republic of China, Department of Medical Research, Chung-Shan Medical University Hospital, Taichung, Taiwan, Republic of China
⨯
Chi-Chih Cheng,

Affiliation Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
⨯
Shih-Lan Hsu,

Affiliations Department of Medical Research, Chung-Shan Medical University Hospital, Taichung, Taiwan, Republic of China, Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China, Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, Republic of China
⨯
Hsiao-Wen Hung,

Affiliation Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
⨯
Jian-Wei Chen ,

Contributed equally to this work with: Jian-Wei Chen, Gee-Chen Chang

* E-mail: jwchen@dragon.nchu.edu.tw (JWC); august@vghtc.gov.tw (GCC)

Affiliation Institute of Biomedical Science, National Chung Hsing University, Taichung, Taiwan, Republic of China
⨯
Gee-Chen Chang

Contributed equally to this work with: Jian-Wei Chen, Gee-Chen Chang

* E-mail: jwchen@dragon.nchu.edu.tw (JWC); august@vghtc.gov.tw (GCC)

Affiliations Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China, Institute of Biomedical Science, National Chung Hsing University, Taichung, Taiwan, Republic of China, Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China
⨯

Pemetrexed Induces S-Phase Arrest and Apoptosis via a Deregulated Activation of Akt Signaling Pathway

Kun-Chieh Chen,
Tsung-Ying Yang,
Chun-Chi Wu,
Chi-Chih Cheng,
Shih-Lan Hsu,
Hsiao-Wen Hung,
Jian-Wei Chen,
Gee-Chen Chang

Published: May 21, 2014
https://doi.org/10.1371/journal.pone.0097888

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Synthesis phase
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Non-small cell lung cancer
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