Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

Open Access

Peer-reviewed

Research Article

Silvia Paoletta,

Affiliation Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Dilip K. Tosh,

Affiliation Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Daniela Salvemini,

Affiliation Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
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Kenneth A. Jacobson

* E-mail: kajacobs@helix.nih.gov

Affiliation Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Adrenergic signal transduction
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G protein coupled receptors
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Drug interactions
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Crystal structure
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Adenosine
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Biogenic amines
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Adenine
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Binding analysis
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