β2-Adrenoceptor Involved in Smoking-Induced Airway Mucus Hypersecretion through β-Arrestin-Dependent Signaling

Yujiao Zhou; Yuan Zhang; Yang Guo; Youyi Zhang; Ming Xu; Bei He

doi:10.1371/journal.pone.0097788

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Peer-reviewed

Research Article

β₂-Adrenoceptor Involved in Smoking-Induced Airway Mucus Hypersecretion through β-Arrestin-Dependent Signaling

Yujiao Zhou,

Affiliation Department of Respiratory Medicine and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, People’s Republic of China
⨯
Yuan Zhang,

Affiliation Department of Respiratory Medicine and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, People’s Republic of China
⨯
Yang Guo,

Affiliation Department of Respiratory Medicine, Changji Renmin Hospital, Changji, Xinjiang, People’s Republic of China
⨯
Youyi Zhang,

Affiliation Department of Respiratory Medicine and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, People’s Republic of China
⨯
Ming Xu ,

* E-mail: puh3_hb@bjmu.edu.cn (BM); xuminghi@bjmu.edu.cn (MX)

Affiliation Department of Respiratory Medicine and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, People’s Republic of China
⨯
Bei He

* E-mail: puh3_hb@bjmu.edu.cn (BM); xuminghi@bjmu.edu.cn (MX)

Affiliation Department of Respiratory Medicine and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, People’s Republic of China
⨯

β₂-Adrenoceptor Involved in Smoking-Induced Airway Mucus Hypersecretion through β-Arrestin-Dependent Signaling

Yujiao Zhou,
Yuan Zhang,
Yang Guo,
Youyi Zhang,
Ming Xu,
Bei He

Published: June 6, 2014
https://doi.org/10.1371/journal.pone.0097788

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Mucus
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Small interfering RNA
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Smoking habits
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Chronic obstructive pulmonary disease
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Mucin
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Gene expression
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Beta-adrenergic antagonist therapy
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Pulmonary function
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