Processive DNA Demethylation via DNA Deaminase-Induced Lesion Resolution

Don-Marc Franchini; Chun-Fung Chan; Hugh Morgan; Elisabetta Incorvaia; Gopinath Rangam; Wendy Dean; Fatima Santos; Wolf Reik; Svend K. Petersen-Mahrt

doi:10.1371/journal.pone.0097754

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Open Access

Peer-reviewed

Research Article

Processive DNA Demethylation via DNA Deaminase-Induced Lesion Resolution

Don-Marc Franchini ,

Contributed equally to this work with: Don-Marc Franchini, Chun-Fung Chan

Affiliations DNA Editing in Immunity and Epigenetics, IFOM-Fondazione Instituto FIRC di Oncologia Molecolare, Milano, Italy, DNA Editing Lab, Clare Hall Laboratories, London Research Institute, South Mimms, United Kingdom
⨯
Chun-Fung Chan ,

Contributed equally to this work with: Don-Marc Franchini, Chun-Fung Chan

Current address: BOYALIFE (INCOSC), Bio-Park, Wuxi, Jiangsu Province, China

Affiliation Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
⨯
Hugh Morgan,

Current address: Human Reproduction Unit, Faculty of Medicine, University of Sydney, Sydney, Australia

Affiliation Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
⨯
Elisabetta Incorvaia,

Affiliation DNA Editing in Immunity and Epigenetics, IFOM-Fondazione Instituto FIRC di Oncologia Molecolare, Milano, Italy
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Gopinath Rangam,

Affiliations DNA Editing in Immunity and Epigenetics, IFOM-Fondazione Instituto FIRC di Oncologia Molecolare, Milano, Italy, DNA Editing Lab, Clare Hall Laboratories, London Research Institute, South Mimms, United Kingdom
⨯
Wendy Dean,

Affiliation Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
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Fatima Santos,

Affiliation Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
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Wolf Reik,

Affiliations Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom, Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom
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Svend K. Petersen-Mahrt

* E-mail: svend.petersen-mahrt@ifom.eu

Affiliations DNA Editing in Immunity and Epigenetics, IFOM-Fondazione Instituto FIRC di Oncologia Molecolare, Milano, Italy, DNA Editing Lab, Clare Hall Laboratories, London Research Institute, South Mimms, United Kingdom
⨯

Processive DNA Demethylation via DNA Deaminase-Induced Lesion Resolution

Don-Marc Franchini,
Chun-Fung Chan,
Hugh Morgan,
Elisabetta Incorvaia,
Gopinath Rangam,
Wendy Dean,
Fatima Santos,
Wolf Reik,
Svend K. Petersen-Mahrt

Published: July 15, 2014
https://doi.org/10.1371/journal.pone.0097754

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DNA methylation
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DNA repair
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Methylation
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Cytosine
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DNA damage
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