Bi-Functionalization of a Calcium Phosphate-Coated Titanium Surface with Slow-Release Simvastatin and Metronidazole to Provide Antibacterial Activities and Pro-Osteodifferentiation Capabilities

• Yunsong Liu ,

  Contributed equally to this work with: Yunsong Liu, Xiao Zhang

  Affiliations Department of Prosthodontics, School and Hospital of Stomatology, Peking University, Beijing, China, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing, China

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• Xiao Zhang ,

  Contributed equally to this work with: Yunsong Liu, Xiao Zhang

  Affiliation Department of Prosthodontics, School and Hospital of Stomatology, Peking University, Beijing, China

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• Yang Liu,

  Affiliation Department of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing, China

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• Xiaoxiao Jin,

  Affiliation Department of Prosthodontics, School and Hospital of Stomatology, Peking University, Beijing, China

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• Cong Fan,

  Affiliation Department of Prosthodontics, School and Hospital of Stomatology, Peking University, Beijing, China

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• Hongqiang Ye,

  Affiliation Department of Prosthodontics, School and Hospital of Stomatology, Peking University, Beijing, China

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• Meng’en Ou,

  Affiliation Department of Prosthodontics, School and Hospital of Stomatology, Peking University, Beijing, China

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• Longwei Lv,

  Affiliation Department of Prosthodontics, School and Hospital of Stomatology, Peking University, Beijing, China

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• Gang Wu,

  Affiliation Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentristry Amsterdam (ACTA), Research Institute MOVE, VU University and University of Amsterdam, Amsterdam, The Netherlands

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• Yongsheng Zhou

  * E-mail: kqzhouysh@hsc.pku.edu.cn

  Affiliations Department of Prosthodontics, School and Hospital of Stomatology, Peking University, Beijing, China, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing, China, Central Laboratory, School and Hospital of Stomatology, Peking University, Beijing, China

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