Identification of the Key Differential Transcriptional Responses of Human Whole Blood Following TLR2 or TLR4 Ligation In-Vitro

Simon Blankley; Christine M. Graham; Ashleigh Howes; Chloe I. Bloom; Matthew P. R. Berry; Damien Chaussabel; Virginia Pascual; Jacques Banchereau; Marc Lipman; Anne O’Garra

doi:10.1371/journal.pone.0097702

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Open Access

Peer-reviewed

Research Article

Identification of the Key Differential Transcriptional Responses of Human Whole Blood Following TLR2 or TLR4 Ligation In-Vitro

Simon Blankley ,

* E-mail: sblankl@nimr.mrc.ac.uk

Affiliation Division of Immunoregulation, MRC National Institute for Medical Research, London, United Kingdom
⨯
Christine M. Graham,

Affiliation Division of Immunoregulation, MRC National Institute for Medical Research, London, United Kingdom
⨯
Ashleigh Howes,

Affiliation Division of Immunoregulation, MRC National Institute for Medical Research, London, United Kingdom
⨯
Chloe I. Bloom,

Affiliation Division of Immunoregulation, MRC National Institute for Medical Research, London, United Kingdom
⨯
Matthew P. R. Berry,

Affiliations Division of Immunoregulation, MRC National Institute for Medical Research, London, United Kingdom, Department of Respiratory Medicine, Imperial College Healthcare NHS trust, London, United Kingdom
⨯
Damien Chaussabel,

Affiliations Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM, Dallas, Texas, United States of America, Systems Immunology, Benaroya Research Institute, Seattle, Washington, United States of America
⨯
Virginia Pascual,

Affiliation Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM, Dallas, Texas, United States of America
⨯
Jacques Banchereau,

Affiliation The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America
⨯
Marc Lipman,

Affiliation Department of Respiratory Medicine, Royal Free London NHS Foundation Trust, University College London, London, United Kingdom
⨯
Anne O’Garra

Affiliations Division of Immunoregulation, MRC National Institute for Medical Research, London, United Kingdom, Department of Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom
⨯

Identification of the Key Differential Transcriptional Responses of Human Whole Blood Following TLR2 or TLR4 Ligation In-Vitro

Simon Blankley,
Christine M. Graham,
Ashleigh Howes,
Chloe I. Bloom,
Matthew P. R. Berry,
Damien Chaussabel,
Virginia Pascual,
Jacques Banchereau,
Marc Lipman,
Anne O’Garra

Published: May 19, 2014
https://doi.org/10.1371/journal.pone.0097702

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Gene expression
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Gene regulation
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Transcriptional control
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Blood
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Regulator genes
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