C-Abl Inhibitor Imatinib Enhances Insulin Production by β Cells: C-Abl Negatively Regulates Insulin Production via Interfering with the Expression of NKx2.2 and GLUT-2

Open Access

Peer-reviewed

Research Article

Chang-Qing Xia ,

* E-mail: cqx65@yahoo.com

Affiliations Department of Hematology, Xuanwu Hospital, Capital Medical University, Bejing, China, Department of Pathology, Immunology and Laboratory Medicine, Diabetes Center of Excellence, University of Florida, Gainesville, Florida, United States of America
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Pengcheng Zhang,

Affiliation Department of Pathology, Immunology and Laboratory Medicine, Diabetes Center of Excellence, University of Florida, Gainesville, Florida, United States of America
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Shiwu Li,

Affiliation Department of Pathology, Immunology and Laboratory Medicine, Diabetes Center of Excellence, University of Florida, Gainesville, Florida, United States of America
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Lihui Yuan,

Affiliation Department of Pathology, Immunology and Laboratory Medicine, Diabetes Center of Excellence, University of Florida, Gainesville, Florida, United States of America
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Tina Xia,

Affiliation Department of Pathology, Immunology and Laboratory Medicine, Diabetes Center of Excellence, University of Florida, Gainesville, Florida, United States of America
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Chao Xie,

Affiliation Department of Pathology, Immunology and Laboratory Medicine, Diabetes Center of Excellence, University of Florida, Gainesville, Florida, United States of America
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Michael J. Clare-Salzler

Affiliation Department of Pathology, Immunology and Laboratory Medicine, Diabetes Center of Excellence, University of Florida, Gainesville, Florida, United States of America
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Insulin
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Glucose
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Gene expression
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Diabetes mellitus
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Transfection
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Gene regulation
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Small interfering RNA
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Reverse transcriptase-polymerase chain reaction
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