The Mechanism of Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

Shuai Li; Jingmiao Zhang; Shaoyong Lu; Wenkang Huang; Lv Geng; Qiancheng Shen; Jian Zhang

doi:10.1371/journal.pone.0097668

Loading metrics

Open Access

Peer-reviewed

Research Article

The Mechanism of Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

Shuai Li ,

Contributed equally to this work with: Shuai Li, Jingmiao Zhang

Affiliation Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine (SJTU-SM), Shanghai, China
⨯
Jingmiao Zhang ,

Contributed equally to this work with: Shuai Li, Jingmiao Zhang

Affiliation Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine (SJTU-SM), Shanghai, China
⨯
Shaoyong Lu,

Affiliation Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine (SJTU-SM), Shanghai, China
⨯
Wenkang Huang,

Affiliation Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine (SJTU-SM), Shanghai, China
⨯
Lv Geng,

Affiliation Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine (SJTU-SM), Shanghai, China
⨯
Qiancheng Shen,

Affiliation Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine (SJTU-SM), Shanghai, China
⨯
Jian Zhang

* E-mail: jian.zhang@sjtu.edu.cn

Affiliations Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai JiaoTong University, School of Medicine (SJTU-SM), Shanghai, China, Medicinal Bioinformatics Center, Shanghai JiaoTong University, School of Medicine, Shanghai, China
⨯

The Mechanism of Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

Shuai Li,
Jingmiao Zhang,
Shaoyong Lu,
Wenkang Huang,
Lv Geng,
Qiancheng Shen,
Jian Zhang

Published: May 15, 2014
https://doi.org/10.1371/journal.pone.0097668

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Biochemical simulations
Is the Subject Area "Biochemical simulations" applicable to this article?

Thanks for your feedback.
Allosteric regulation
Is the Subject Area "Allosteric regulation" applicable to this article?

Thanks for your feedback.
Biophysical simulations
Is the Subject Area "Biophysical simulations" applicable to this article?

Thanks for your feedback.
Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.
Principal component analysis
Is the Subject Area "Principal component analysis" applicable to this article?

Thanks for your feedback.
Protein structure
Is the Subject Area "Protein structure" applicable to this article?

Thanks for your feedback.
Phosphatases
Is the Subject Area "Phosphatases" applicable to this article?

Thanks for your feedback.
Tyrosine
Is the Subject Area "Tyrosine" applicable to this article?

Thanks for your feedback.