The C-Terminal Random Coil Region Tunes the Ca²⁺-Binding Affinity of S100A4 through Conformational Activation

• Annette Duelli ,

  Contributed equally to this work with: Annette Duelli, Bence Kiss

  Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden

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• Bence Kiss ,

  Contributed equally to this work with: Annette Duelli, Bence Kiss

  Affiliation Department of Biochemistry, Eötvös Loránd University, Budapest, Hungary

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• Ida Lundholm,

  Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden

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• Andrea Bodor,

  Affiliation Institute of Chemistry, Laboratory of Structural Chemistry and Biology, Eötvös Loránd University, Budapest, Hungary

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• Maxim V. Petoukhov,

  Affiliation European Molecular Biology Laboratory (EMBL), Hamburg Outstation c/o DESY, Hamburg, Germany

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• Dmitri I. Svergun,

  Affiliation European Molecular Biology Laboratory (EMBL), Hamburg Outstation c/o DESY, Hamburg, Germany

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• László Nyitray ,

  * E-mail: nyitray@elte.hu (LN); gergely.katona@cmb.gu.se (GK)

  Affiliation Department of Biochemistry, Eötvös Loránd University, Budapest, Hungary

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• Gergely Katona

  * E-mail: nyitray@elte.hu (LN); gergely.katona@cmb.gu.se (GK)

  Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden

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