Targeting Prolyl Endopeptidase with Valproic Acid as a Potential Modulator of Neutrophilic Inflammation

Mojtaba Abdul Roda; Mariam Sadik; Amit Gaggar; Matthew T. Hardison; Michael J. Jablonsky; Saskia Braber; James Edwin Blalock; Frank A. Redegeld; Gert Folkerts; Patricia L. Jackson

doi:10.1371/journal.pone.0097594

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Open Access

Peer-reviewed

Research Article

Targeting Prolyl Endopeptidase with Valproic Acid as a Potential Modulator of Neutrophilic Inflammation

Mojtaba Abdul Roda ,

* E-mail: m.abdulroda@uu.nl

Affiliations Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Mariam Sadik,

Affiliations Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Amit Gaggar,

Affiliation Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Matthew T. Hardison,

Affiliation Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Michael J. Jablonsky,

Affiliation Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Saskia Braber,

Affiliation Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands
⨯
James Edwin Blalock,

Affiliation Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Frank A. Redegeld,

Affiliation Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Gert Folkerts,

Affiliation Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands
⨯
Patricia L. Jackson

Affiliation Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

Targeting Prolyl Endopeptidase with Valproic Acid as a Potential Modulator of Neutrophilic Inflammation

Mojtaba Abdul Roda,
Mariam Sadik,
Amit Gaggar,
Matthew T. Hardison,
Michael J. Jablonsky,
Saskia Braber,
James Edwin Blalock,
Frank A. Redegeld,
Gert Folkerts,
Patricia L. Jackson

Published: May 16, 2014
https://doi.org/10.1371/journal.pone.0097594

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