AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication

Nicholas D. Weber; Daniel Stone; Ruth Hall Sedlak; Harshana S. De Silva Feelixge; Pavitra Roychoudhury; Joshua T. Schiffer; Martine Aubert; Keith R. Jerome

doi:10.1371/journal.pone.0097579

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Open Access

Peer-reviewed

Research Article

AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication

Nicholas D. Weber,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America
⨯
Daniel Stone,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Ruth Hall Sedlak,

Affiliation Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America
⨯
Harshana S. De Silva Feelixge,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Pavitra Roychoudhury,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Joshua T. Schiffer,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Division of Allergy and Infectious Disease, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Martine Aubert,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Keith R. Jerome

* E-mail: kjerome@fhcrc.org

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America, Department of Microbiology, University of Washington, Seattle, Washington, United States of America
⨯

AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication

Nicholas D. Weber,
Daniel Stone,
Ruth Hall Sedlak,
Harshana S. De Silva Feelixge,
Pavitra Roychoudhury,
Joshua T. Schiffer,
Martine Aubert,
Keith R. Jerome

Published: May 14, 2014
https://doi.org/10.1371/journal.pone.0097579

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Zinc finger nucleases
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Hepatitis B virus
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Polymerase chain reaction
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Antiviral therapy
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