Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular Simulations

Li-Dong Huang; Ying-Zhe Fan; Yun Tian; Yang Yang; Yan Liu; Jin Wang; Wen-Shan Zhao; Wen-Chao Zhou; Xiao-Yang Cheng; Peng Cao; Xiang-Yang Lu; Ye Yu

doi:10.1371/journal.pone.0097528

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Open Access

Peer-reviewed

Research Article

Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular Simulations

Li-Dong Huang ,

Contributed equally to this work with: Li-Dong Huang, Ying-Zhe Fan

Affiliation Department of Pharmacology and Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Ying-Zhe Fan ,

Contributed equally to this work with: Li-Dong Huang, Ying-Zhe Fan

Affiliation Putuo District Center Hospital, Shanghai University of Chinese Traditional Medicine, Shanghai, China
⨯
Yun Tian,

Affiliation College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China
⨯
Yang Yang,

Affiliation Department of Pharmacology and Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Yan Liu,

Affiliation Department of Pharmacology and Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Jin Wang,

Affiliation Department of Pharmacology and Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Wen-Shan Zhao,

Affiliation Department of Pharmacology and Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Wen-Chao Zhou,

Affiliations Department of Pharmacology and Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Putuo District Center Hospital, Shanghai University of Chinese Traditional Medicine, Shanghai, China
⨯
Xiao-Yang Cheng,

Affiliation Department of Pharmacology and Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Peng Cao,

Affiliation Jiangsu Province Institute of Traditional Chinese Medicine, Nanjing, Jiangsu, China
⨯
Xiang-Yang Lu,

Affiliation College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China
⨯
Ye Yu

* E-mail: yuye@shsmu.edu.cn

Affiliations Department of Pharmacology and Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China, College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China
⨯

Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular Simulations

Li-Dong Huang,
Ying-Zhe Fan,
Yun Tian,
Yang Yang,
Yan Liu,
Jin Wang,
Wen-Shan Zhao,
Wen-Chao Zhou,
Xiao-Yang Cheng,
Peng Cao

Published: May 30, 2014
https://doi.org/10.1371/journal.pone.0097528

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