Rational Design of Berberine-Based FtsZ Inhibitors with Broad-Spectrum Antibacterial Activity

• Ning Sun,

  Affiliation Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

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• Fung-Yi Chan,

  Affiliations Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

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• Yu-Jing Lu,

  Affiliations Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China

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• Marco A. C. Neves,

  Affiliation Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

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• Hok-Kiu Lui,

  Affiliation Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

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• Yong Wang,

  Affiliation Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

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• Ka-Yan Chow,

  Affiliation Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

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• Kin-Fai Chan,

  Affiliation Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

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• Siu-Cheong Yan,

  Affiliation Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

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• Yun-Chung Leung,

  Affiliation Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

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• Ruben Abagyan,

  Affiliations Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America, Molsoft L.L.C, San Diego, California, United States of America

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• Tak-Hang Chan,

  Affiliation Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

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• Kwok-Yin Wong

  * E-mail: kwok-yin.wong@polyu.edu.hk

  Affiliation Department of Applied Biology and Chemical Technology and the State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

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