TU-100 (Daikenchuto) and Ginger Ameliorate Anti-CD3 Antibody Induced T Cell-Mediated Murine Enteritis: Microbe-Independent Effects Involving Akt and NF-κB Suppression

Nobuhiro Ueno; Takumu Hasebe; Atsushi Kaneko; Masahiro Yamamoto; Mikihiro Fujiya; Yutaka Kohgo; Toru Kono; Chong-Zhi Wang; Chun-Su Yuan; Marc Bissonnette; Eugene B. Chang; Mark W. Musch

doi:10.1371/journal.pone.0097456

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Peer-reviewed

Research Article

TU-100 (Daikenchuto) and Ginger Ameliorate Anti-CD3 Antibody Induced T Cell-Mediated Murine Enteritis: Microbe-Independent Effects Involving Akt and NF-κB Suppression

Nobuhiro Ueno,

Affiliations Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, Illinois, United States of America, Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
⨯
Takumu Hasebe,

Affiliations Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, Illinois, United States of America, Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
⨯
Atsushi Kaneko,

Affiliation Tsumura Research Laboratories, Tsumura and Co., Ami, Ibaraki, Japan
⨯
Masahiro Yamamoto,

Affiliation Tsumura Research Laboratories, Tsumura and Co., Ami, Ibaraki, Japan
⨯
Mikihiro Fujiya,

Affiliation Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
⨯
Yutaka Kohgo,

Affiliation Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
⨯
Toru Kono,

Affiliations Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan, Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
⨯
Chong-Zhi Wang,

Affiliation Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, United States of America
⨯
Chun-Su Yuan,

Affiliation Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, United States of America
⨯
Marc Bissonnette,

Affiliation Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, Illinois, United States of America
⨯
Eugene B. Chang,

Affiliation Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, Illinois, United States of America
⨯
Mark W. Musch

* E-mail: mmusch@medicine.bsd.uchicago.edu

Affiliation Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, Illinois, United States of America
⨯

TU-100 (Daikenchuto) and Ginger Ameliorate Anti-CD3 Antibody Induced T Cell-Mediated Murine Enteritis: Microbe-Independent Effects Involving Akt and NF-κB Suppression

Nobuhiro Ueno,
Takumu Hasebe,
Atsushi Kaneko,
Masahiro Yamamoto,
Mikihiro Fujiya,
Yutaka Kohgo,
Toru Kono,
Chong-Zhi Wang,
Chun-Su Yuan,
Marc Bissonnette

Published: May 23, 2014
https://doi.org/10.1371/journal.pone.0097456

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