Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins)

Agustín Correa; Sabino Pacheco; Ariel E. Mechaly; Gonzalo Obal; Ghislaine Béhar; Barbara Mouratou; Pablo Oppezzo; Pedro M. Alzari; Frédéric Pecorari

doi:10.1371/journal.pone.0097438

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Open Access

Peer-reviewed

Research Article

Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins)

Agustín Correa ,

Contributed equally to this work with: Agustín Correa, Sabino Pacheco

Affiliations Institut Pasteur de Montevideo, Recombinant Protein Unit, Montevideo, Uruguay, Institut Pasteur, Unité de Microbiologie Structurale, CNRS UMR 3528, Paris, France
⨯
Sabino Pacheco ,

Contributed equally to this work with: Agustín Correa, Sabino Pacheco

Affiliations Institut Pasteur, Unité de Microbiologie Structurale, CNRS UMR 3528, Paris, France, INSERM UMR 892 - CRCNA, Nantes, France, CNRS UMR 6299, Nantes, France, University of Nantes, Nantes, France
⨯
Ariel E. Mechaly,

Current address: Institut Pasteur de Montevideo, Unit of Protein Crystallography, Montevideo, Uruguay

Affiliation Institut Pasteur, Unité de Microbiologie Structurale, CNRS UMR 3528, Paris, France
⨯
Gonzalo Obal,

Affiliation Institut Pasteur de Montevideo, Protein Biophysics Unit, Montevideo, Uruguay
⨯
Ghislaine Béhar,

Affiliations INSERM UMR 892 - CRCNA, Nantes, France, CNRS UMR 6299, Nantes, France, University of Nantes, Nantes, France
⨯
Barbara Mouratou,

Affiliations INSERM UMR 892 - CRCNA, Nantes, France, CNRS UMR 6299, Nantes, France, University of Nantes, Nantes, France
⨯
Pablo Oppezzo,

Affiliation Institut Pasteur de Montevideo, Recombinant Protein Unit, Montevideo, Uruguay
⨯
Pedro M. Alzari,

Affiliation Institut Pasteur, Unité de Microbiologie Structurale, CNRS UMR 3528, Paris, France
⨯
Frédéric Pecorari

* E-mail: frederic.pecorari@univ-nantes.fr

Affiliations INSERM UMR 892 - CRCNA, Nantes, France, CNRS UMR 6299, Nantes, France, University of Nantes, Nantes, France
⨯

Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins)

Agustín Correa,
Sabino Pacheco,
Ariel E. Mechaly,
Gonzalo Obal,
Ghislaine Béhar,
Barbara Mouratou,
Pablo Oppezzo,
Pedro M. Alzari,
Frédéric Pecorari

Published: May 13, 2014
https://doi.org/10.1371/journal.pone.0097438

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