Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation

Liang Liu; Hamid Reza Rezvani; Jung Ho Back; Mohsen Hosseini; Xiuwei Tang; Yucui Zhu; Walid Mahfouf; Houssam Raad; Grace Raji; Mohammad Athar; Arianna L. Kim; David R. Bickers

doi:10.1371/journal.pone.0097245

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Peer-reviewed

Research Article

Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation

Liang Liu,

Affiliation Department of Dermatology, Columbia University Medical Center, New York, New York, United States of America
⨯
Hamid Reza Rezvani,

Affiliations Biothérapies des maladies génétiques et cancers, Univ. de Bordeaux, Bordeaux, France, INSERM, Biothérapies des maladies génétiques et cancers, Bordeaux, France
⨯
Jung Ho Back,

Affiliation Department of Dermatology, Columbia University Medical Center, New York, New York, United States of America
⨯
Mohsen Hosseini,

Affiliations Biothérapies des maladies génétiques et cancers, Univ. de Bordeaux, Bordeaux, France, INSERM, Biothérapies des maladies génétiques et cancers, Bordeaux, France
⨯
Xiuwei Tang,

Affiliation Department of Dermatology, Columbia University Medical Center, New York, New York, United States of America
⨯
Yucui Zhu,

Affiliation Department of Dermatology, Columbia University Medical Center, New York, New York, United States of America
⨯
Walid Mahfouf,

Affiliations Biothérapies des maladies génétiques et cancers, Univ. de Bordeaux, Bordeaux, France, INSERM, Biothérapies des maladies génétiques et cancers, Bordeaux, France
⨯
Houssam Raad,

Affiliations Biothérapies des maladies génétiques et cancers, Univ. de Bordeaux, Bordeaux, France, INSERM, Biothérapies des maladies génétiques et cancers, Bordeaux, France
⨯
Grace Raji,

Affiliation Department of Dermatology, Columbia University Medical Center, New York, New York, United States of America
⨯
Mohammad Athar,

Affiliation Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Arianna L. Kim ,

* E-mail: ak309@columbia.edu (AK); ak309@columbia.edu (DB)

Affiliation Department of Dermatology, Columbia University Medical Center, New York, New York, United States of America
⨯
David R. Bickers

* E-mail: ak309@columbia.edu (AK); ak309@columbia.edu (DB)

Affiliation Department of Dermatology, Columbia University Medical Center, New York, New York, United States of America
⨯

Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation

Liang Liu,
Hamid Reza Rezvani,
Jung Ho Back,
Mohsen Hosseini,
Xiuwei Tang,
Yucui Zhu,
Walid Mahfouf,
Houssam Raad,
Grace Raji,
Mohammad Athar

Published: May 13, 2014
https://doi.org/10.1371/journal.pone.0097245

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Skin tumors
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Carcinogenesis
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Mouse models
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Malignant tumors
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Keratinocytes
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Squamous cell carcinoma
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MAPK signaling cascades
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Small interfering RNA
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