Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies

Anne-Sophie Dugast; Ying Chan; Michelle Hoffner; Anna Licht; Joseph Nkolola; Hualin Li; Hendrik Streeck; Todd J. Suscovich; Musie Ghebremichael; Margaret E. Ackerman; Dan H. Barouch; Galit Alter

doi:10.1371/journal.pone.0097229

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Open Access

Peer-reviewed

Research Article

Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies

Anne-Sophie Dugast,

Affiliation Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Ying Chan,

Affiliation Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Michelle Hoffner,

Affiliation Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Anna Licht,

Affiliation Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Joseph Nkolola,

Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Hualin Li,

Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Hendrik Streeck,

Affiliation Military HIV Research Program, Henry Jackson Foundation, Rockville, Maryland, United States of America
⨯
Todd J. Suscovich,

Affiliation Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Musie Ghebremichael,

Affiliation Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Margaret E. Ackerman,

Affiliation Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, United States of America
⨯
Dan H. Barouch,

Affiliations Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Galit Alter

* E-mail: galter@partners.org

Affiliation Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯

Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies

Anne-Sophie Dugast,
Ying Chan,
Michelle Hoffner,
Anna Licht,
Joseph Nkolola,
Hualin Li,
Hendrik Streeck,
Todd J. Suscovich,
Musie Ghebremichael,
Margaret E. Ackerman

Published: May 12, 2014
https://doi.org/10.1371/journal.pone.0097229

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