Virus-Mediated shRNA Knockdown of Prodynorphin in the Rat Nucleus Accumbens Attenuates Depression-Like Behavior and Cocaine Locomotor Sensitization

Ami Cohen; Timothy W. Whitfield; Max Kreifeldt; Pascale Koebel; Brigitte L. Kieffer; Candice Contet; Olivier George; George F. Koob

doi:10.1371/journal.pone.0097216

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Research Article

Virus-Mediated shRNA Knockdown of Prodynorphin in the Rat Nucleus Accumbens Attenuates Depression-Like Behavior and Cocaine Locomotor Sensitization

Ami Cohen ,

* E-mail: cohen@scripps.edu

¶These authors are co-first authors on this work.

Affiliation Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Timothy W. Whitfield ,

¶These authors are co-first authors on this work.

Affiliation Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Max Kreifeldt,

Affiliation Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Pascale Koebel,

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, Translational Medicine and Neurogenetic Programme, UdS Université de Strasbourg, INSERM U964, CNRS UMR7104, Illkirch, France
⨯
Brigitte L. Kieffer,

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, Translational Medicine and Neurogenetic Programme, UdS Université de Strasbourg, INSERM U964, CNRS UMR7104, Illkirch, France
⨯
Candice Contet,

Affiliation Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Olivier George,

Affiliation Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, United States of America
⨯
George F. Koob

Affiliation Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, United States of America
⨯

Virus-Mediated shRNA Knockdown of Prodynorphin in the Rat Nucleus Accumbens Attenuates Depression-Like Behavior and Cocaine Locomotor Sensitization

Ami Cohen,
Timothy W. Whitfield,
Max Kreifeldt,
Pascale Koebel,
Brigitte L. Kieffer,
Candice Contet,
Olivier George,
George F. Koob

Published: May 9, 2014
https://doi.org/10.1371/journal.pone.0097216

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