Regulation and Novel Action of Thymidine Phosphorylase in Non-Small Cell Lung Cancer: Crosstalk with Nrf2 and HO-1

Magdalena Tertil; Klaudia Skrzypek; Urszula Florczyk; Kazimierz Weglarczyk; Halina Was; Guillaume Collet; Alan Guichard; Tomasz Gil; Jaroslaw Kuzdzal; Alicja Jozkowicz; Claudine Kieda; Chantal Pichon; Jozef Dulak

doi:10.1371/journal.pone.0097070

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Open Access

Peer-reviewed

Research Article

Regulation and Novel Action of Thymidine Phosphorylase in Non-Small Cell Lung Cancer: Crosstalk with Nrf2 and HO-1

Magdalena Tertil,

Affiliations Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland, Centre de Biophysique Moleculaire, CNRS UPR4301, Orléans, France, Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
⨯
Klaudia Skrzypek,

Current address: Department of Transplantation, Polish-American Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland

Affiliations Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland, Centre de Biophysique Moleculaire, CNRS UPR4301, Orléans, France
⨯
Urszula Florczyk,

Affiliation Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
⨯
Kazimierz Weglarczyk,

Current address: Department of Clinical Immunology, Polish-American Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland

Affiliation Centre de Biophysique Moleculaire, CNRS UPR4301, Orléans, France
⨯
Halina Was,

Current address: Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, Warsaw, Poland

Affiliation Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
⨯
Guillaume Collet,

Affiliation Centre de Biophysique Moleculaire, CNRS UPR4301, Orléans, France
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Alan Guichard,

Current address: Unité Mixte de Recherche Compartimentation et Dynamique Cellulaires, Institut Curie, Paris, France

Affiliation Centre de Biophysique Moleculaire, CNRS UPR4301, Orléans, France
⨯
Tomasz Gil,

Affiliation Department of Thoracic Surgery, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
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Jaroslaw Kuzdzal,

Affiliation Department of Thoracic Surgery, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
⨯
Alicja Jozkowicz,

Affiliation Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
⨯
Claudine Kieda,

Affiliation Centre de Biophysique Moleculaire, CNRS UPR4301, Orléans, France
⨯
Chantal Pichon ,

Contributed equally to this work with: Chantal Pichon, Jozef Dulak

Affiliation Centre de Biophysique Moleculaire, CNRS UPR4301, Orléans, France
⨯
Jozef Dulak

Contributed equally to this work with: Chantal Pichon, Jozef Dulak

* E-mail: jozef.dulak@uj.edu.pl

Affiliation Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
⨯

Regulation and Novel Action of Thymidine Phosphorylase in Non-Small Cell Lung Cancer: Crosstalk with Nrf2 and HO-1

Magdalena Tertil,
Klaudia Skrzypek,
Urszula Florczyk,
Kazimierz Weglarczyk,
Halina Was,
Guillaume Collet,
Alan Guichard,
Tomasz Gil,
Jaroslaw Kuzdzal,
Alicja Jozkowicz

Published: May 12, 2014
https://doi.org/10.1371/journal.pone.0097070

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Non-small cell lung cancer
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Endothelial cells
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Hyperexpression techniques
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Thymidines
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