Transition of LINE-1 DNA Methylation Status and Altered Expression in First and Third Trimester Placentas

Zhi-ming He; Jinping Li; Yi Lisa Hwa; Brian Brost; Qun Fang; Shi-Wen Jiang

doi:10.1371/journal.pone.0096994

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Open Access

Peer-reviewed

Research Article

Transition of LINE-1 DNA Methylation Status and Altered Expression in First and Third Trimester Placentas

Zhi-ming He ,

Contributed equally to this work with: Zhi-ming He, Jinping Li

Affiliations Fetal Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, Department of Biological Science, Mercer University School of Medicine, Savannah, Georgia, United States of America
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Jinping Li ,

Contributed equally to this work with: Zhi-ming He, Jinping Li

Affiliations Department of Biological Science, Mercer University School of Medicine, Savannah, Georgia, United States of America, Department of Obstetrics and Gynecology, Mayo Clinic and Mayo College of Medicine, Rochester, Minnesota, United States of America, Department of Obstetrics and Gynecology, Memorial Health University Medical Center, Savannah, Georgia, United States of America
⨯
Yi Lisa Hwa,

Affiliation Department of Medicine, Mayo Clinic and Mayo College of Medicine, Rochester, Minnesota, United States of America
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Brian Brost,

Affiliation Department of Obstetrics and Gynecology, Mayo Clinic and Mayo College of Medicine, Rochester, Minnesota, United States of America
⨯
Qun Fang ,

* E-mail: jiang_s@mercer.edu (S-WJ); fang_qun@163.com (QF)

Affiliation Fetal Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Shi-Wen Jiang

* E-mail: jiang_s@mercer.edu (S-WJ); fang_qun@163.com (QF)

Affiliations Department of Biological Science, Mercer University School of Medicine, Savannah, Georgia, United States of America, Department of Obstetrics and Gynecology, Mayo Clinic and Mayo College of Medicine, Rochester, Minnesota, United States of America, Department of Obstetrics and Gynecology, Memorial Health University Medical Center, Savannah, Georgia, United States of America
⨯

Transition of LINE-1 DNA Methylation Status and Altered Expression in First and Third Trimester Placentas

Zhi-ming He,
Jinping Li,
Yi Lisa Hwa,
Brian Brost,
Qun Fang,
Shi-Wen Jiang

Published: May 12, 2014
https://doi.org/10.1371/journal.pone.0096994

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DNA methylation
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Pregnancy
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Polymerase chain reaction
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Methylation
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Cell proliferation
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Combined bisulfite restriction analysis
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Gene expression
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