Glycoengineering of Interferon-β 1a Improves Its Biophysical and Pharmacokinetic Properties

Kyoung Song; In-Soo Yoon; Nam Ah Kim; Dong-Hwan Kim; Jongmin Lee; Hee Jung Lee; Saehyung Lee; Sunghyun Choi; Min-Koo Choi; Ha Hyung Kim; Seong Hoon Jeong; Woo Sung Son; Dae-Duk Kim; Young Kee Shin

doi:10.1371/journal.pone.0096967

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Open Access

Peer-reviewed

Research Article

Glycoengineering of Interferon-β 1a Improves Its Biophysical and Pharmacokinetic Properties

Kyoung Song,

Affiliations College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea, Research Institute of Reference Biolabs. Inc., Seoul, Republic of Korea
⨯
In-Soo Yoon,

Affiliation College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, Republic of Korea
⨯
Nam Ah Kim,

Affiliation College of Pharmacy, Dongguk University-Seoul, Gyeonggi-do, Republic of Korea
⨯
Dong-Hwan Kim,

Affiliation College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
⨯
Jongmin Lee,

Affiliation PanGen Biotech Inc., Gyeonggi-do, Republic of Korea
⨯
Hee Jung Lee,

Affiliation Research Institute of Reference Biolabs. Inc., Seoul, Republic of Korea
⨯
Saehyung Lee,

Affiliation College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
⨯
Sunghyun Choi,

Affiliation Research Institute of Reference Biolabs. Inc., Seoul, Republic of Korea
⨯
Min-Koo Choi,

Affiliation College of Pharmacy, DanKook University, Chungnam, Republic of Korea
⨯
Ha Hyung Kim,

Affiliation Biotherapeutics and Glycomics Laboratory, College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea
⨯
Seong Hoon Jeong,

Affiliation College of Pharmacy, Dongguk University-Seoul, Gyeonggi-do, Republic of Korea
⨯
Woo Sung Son,

Affiliation College of Pharmacy, CHA University, Gyeonggi-do, Republic of Korea
⨯
Dae-Duk Kim,

Affiliation College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
⨯
Young Kee Shin

* E-mail: ykeeshin@snu.ac.kr

Affiliations College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea, Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul, Republic of Korea
⨯

Glycoengineering of Interferon-β 1a Improves Its Biophysical and Pharmacokinetic Properties

Kyoung Song,
In-Soo Yoon,
Nam Ah Kim,
Dong-Hwan Kim,
Jongmin Lee,
Hee Jung Lee,
Saehyung Lee,
Sunghyun Choi,
Min-Koo Choi,
Ha Hyung Kim

Published: May 23, 2014
https://doi.org/10.1371/journal.pone.0096967

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