Human Osteoarthritic Cartilage Shows Reduced In Vivo Expression of IL-4, a Chondroprotective Cytokine that Differentially Modulates IL-1β-Stimulated Production of Chemokines and Matrix-Degrading Enzymes In Vitro

Elisa Assirelli; Lia Pulsatelli; Paolo Dolzani; Daniela Platano; Eleonora Olivotto; Giuseppe Filardo; Giovanni Trisolino; Andrea Facchini; Rosa Maria Borzì; Riccardo Meliconi

doi:10.1371/journal.pone.0096925

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Research Article

Human Osteoarthritic Cartilage Shows Reduced In Vivo Expression of IL-4, a Chondroprotective Cytokine that Differentially Modulates IL-1β-Stimulated Production of Chemokines and Matrix-Degrading Enzymes In Vitro

Elisa Assirelli,

Affiliation Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopaedic Institute, Bologna, Italy
⨯
Lia Pulsatelli,

Affiliation Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopaedic Institute, Bologna, Italy
⨯
Paolo Dolzani,

Affiliation Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopaedic Institute, Bologna, Italy
⨯
Daniela Platano,

Affiliation Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopaedic Institute, Bologna, Italy
⨯
Eleonora Olivotto,

Affiliation Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopaedic Institute, Bologna, Italy
⨯
Giuseppe Filardo,

Affiliation Laboratory of Biomechanics and Technology Innovation, 2nd Orthopaedic and Traumatologic Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy
⨯
Giovanni Trisolino,

Affiliation Reconstructive Hip and Knee Joint Surgery, Rizzoli Orthopaedic Institute, Bologna, Italy
⨯
Andrea Facchini,

Affiliations Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopaedic Institute, Bologna, Italy, University of Bologna, Bologna, Italy
⨯
Rosa Maria Borzì,

Affiliation Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopaedic Institute, Bologna, Italy
⨯
Riccardo Meliconi

* E-mail: riccardo.meliconi@unibo.it

Affiliations University of Bologna, Bologna, Italy, Medicine and Rheumatology Unit, Rizzoli Orthopaedic Institute, Bologna, Italy
⨯

Human Osteoarthritic Cartilage Shows Reduced In Vivo Expression of IL-4, a Chondroprotective Cytokine that Differentially Modulates IL-1β-Stimulated Production of Chemokines and Matrix-Degrading Enzymes In Vitro

Elisa Assirelli,
Lia Pulsatelli,
Paolo Dolzani,
Daniela Platano,
Eleonora Olivotto,
Giuseppe Filardo,
Giovanni Trisolino,
Andrea Facchini,
Rosa Maria Borzì,
Riccardo Meliconi

Published: May 12, 2014
https://doi.org/10.1371/journal.pone.0096925

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Cartilage
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Chondrocytes
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Osteoarthritis
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Chemokines
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Extracellular matrix
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Extracellular matrix proteins
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Protein expression
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