Fast Skeletal Muscle Troponin Activator tirasemtiv Increases Muscle Function and Performance in the B6SJL-SOD1G93A ALS Mouse Model

Open Access

Peer-reviewed

Research Article

Fast Skeletal Muscle Troponin Activator tirasemtiv Increases Muscle Function and Performance in the B6SJL-SOD1^G93A ALS Mouse Model

Darren T. Hwee ,

Contributed equally to this work with: Darren T. Hwee, Adam Kennedy

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America
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Adam Kennedy ,

Contributed equally to this work with: Darren T. Hwee, Adam Kennedy

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America
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Julie Ryans,

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America
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Alan J. Russell,

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America
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Zhiheng Jia,

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America
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Aaron C. Hinken,

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America
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David J. Morgans,

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America
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Fady I. Malik,

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America
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Jeffrey R. Jasper

* E-mail: jjasper@cytokinetics.com

Affiliation Cytokinetics, Inc., South San Francisco, California, United States of America
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Mouse models
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Hand strength
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Animal performance
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Genetically modified animals
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Skeletal muscles
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Muscle functions
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Thoracic diaphragm
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Tidal volume
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