Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion

Evan Gomes-Giacoia; Makito Miyake; Steve Goodison; Aravindhan Sriharan; Ge Zhang; Lijing You; Jack O. Egan; Peter R. Rhode; Alexander S. Parker; Karl X. Chai; Hing C. Wong; Charles J. Rosser

doi:10.1371/journal.pone.0096705

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Open Access

Peer-reviewed

Research Article

Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion

Evan Gomes-Giacoia ,

Contributed equally to this work with: Evan Gomes-Giacoia, Makito Miyake

Affiliation Cancer Research Institute, MD Anderson Cancer Center Orlando, Orlando, Florida, United States of America
⨯
Makito Miyake ,

Contributed equally to this work with: Evan Gomes-Giacoia, Makito Miyake

Affiliation Cancer Research Institute, MD Anderson Cancer Center Orlando, Orlando, Florida, United States of America
⨯
Steve Goodison,

Affiliations Cancer Research Institute, MD Anderson Cancer Center Orlando, Orlando, Florida, United States of America, Department of Health Sciences Research, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Aravindhan Sriharan,

Affiliation Department of Pathology, MD Anderson Cancer Center Orlando, Orlando, Florida, United States of America
⨯
Ge Zhang,

Affiliation Cancer Research Institute, MD Anderson Cancer Center Orlando, Orlando, Florida, United States of America
⨯
Lijing You,

Affiliation Altor Bioscience Corporation, Miramar, Florida, United States of America
⨯
Jack O. Egan,

Affiliation Altor Bioscience Corporation, Miramar, Florida, United States of America
⨯
Peter R. Rhode,

Affiliation Altor Bioscience Corporation, Miramar, Florida, United States of America
⨯
Alexander S. Parker,

Affiliation Department of Health Sciences Research, Mayo Clinic, Jacksonville, Florida, United States of America
⨯
Karl X. Chai,

Affiliation Burnett College of Biomedical Sciences, University of Central Florida, Orlando, Florida, United States of America
⨯
Hing C. Wong,

Affiliation Altor Bioscience Corporation, Miramar, Florida, United States of America
⨯
Charles J. Rosser

* E-mail: cjrosser@hawaii.edu

Affiliations Cancer Research Institute, MD Anderson Cancer Center Orlando, Orlando, Florida, United States of America, Clinical and Translational Research, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
⨯

Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion

Evan Gomes-Giacoia,
Makito Miyake,
Steve Goodison,
Aravindhan Sriharan,
Ge Zhang,
Lijing You,
Jack O. Egan,
Peter R. Rhode,
Alexander S. Parker,
Karl X. Chai

Published: June 4, 2014
https://doi.org/10.1371/journal.pone.0096705

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