The Repressive Effect of miR-148a on TGF beta-SMADs Signal Pathway Is Involved in the Glabridin-Induced Inhibition of the Cancer Stem Cells-Like Properties in Hepatocellular Carcinoma Cells

Fei Jiang; Juan Mu; Xingxing Wang; Xianqing Ye; Lu Si; Shilong Ning; Zhong Li; Yuan Li

doi:10.1371/journal.pone.0096698

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Open Access

Peer-reviewed

Research Article

The Repressive Effect of miR-148a on TGF beta-SMADs Signal Pathway Is Involved in the Glabridin-Induced Inhibition of the Cancer Stem Cells-Like Properties in Hepatocellular Carcinoma Cells

Fei Jiang,

Affiliation Department of Nutrition and Food Hygiene, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
⨯
Juan Mu,

Affiliation Department of Nutrition and Food Hygiene, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
⨯
Xingxing Wang,

Affiliation Department of Nutrition and Food Hygiene, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
⨯
Xianqing Ye,

Affiliation Department of Nutrition and Food Hygiene, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
⨯
Lu Si,

Affiliation Department of Nutrition and Food Hygiene, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
⨯
Shilong Ning,

Affiliation Department of Nutrition and Food Hygiene, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
⨯
Zhong Li ,

* E-mail: lz-ny@njmu.edu.cn (ZL); liyuannjmu@hotmail.com (YL)

Affiliation Department of Nutrition and Food Hygiene, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
⨯
Yuan Li

* E-mail: lz-ny@njmu.edu.cn (ZL); liyuannjmu@hotmail.com (YL)

Affiliation Department of Nutrition and Food Hygiene, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China
⨯

The Repressive Effect of miR-148a on TGF beta-SMADs Signal Pathway Is Involved in the Glabridin-Induced Inhibition of the Cancer Stem Cells-Like Properties in Hepatocellular Carcinoma Cells

Fei Jiang,
Juan Mu,
Xingxing Wang,
Xianqing Ye,
Lu Si,
Shilong Ning,
Zhong Li,
Yuan Li

Published: May 7, 2014
https://doi.org/10.1371/journal.pone.0096698

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Hepatocellular carcinoma
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Transfection
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Cancer treatment
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Reverse transcriptase-polymerase chain reaction
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Signal inhibition
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Cancer stem cells
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SMAD signaling
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