Silencing Herpes Simplex Virus Type 1 Capsid Protein Encoding Genes by siRNA: A Promising Antiviral Therapeutic Approach

Fujun Jin; Shen Li; Kai Zheng; Cuiqin Zhuo; Kaiqi Ma; Maoyun Chen; Qiaoli Wang; Peizhuo Zhang; Jianglin Fan; Zhe Ren; Yifei Wang

doi:10.1371/journal.pone.0096623

Loading metrics

Open Access

Peer-reviewed

Research Article

Silencing Herpes Simplex Virus Type 1 Capsid Protein Encoding Genes by siRNA: A Promising Antiviral Therapeutic Approach

Fujun Jin ,

Contributed equally to this work with: Fujun Jin, Shen Li

Affiliations Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, Guangdong, China, College of Pharmacy, Jinan University, Guangzhou, Guangdong, China
⨯
Shen Li ,

Contributed equally to this work with: Fujun Jin, Shen Li

Affiliation Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
⨯
Kai Zheng,

Affiliation Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Cuiqin Zhuo,

Affiliations Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, Guangdong, China, College of Pharmacy, Jinan University, Guangzhou, Guangdong, China
⨯
Kaiqi Ma,

Affiliation Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Maoyun Chen,

Affiliations Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, Guangdong, China, College of Pharmacy, Jinan University, Guangzhou, Guangdong, China
⨯
Qiaoli Wang,

Affiliation Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Peizhuo Zhang,

Affiliation Shanghai GenePharma Co., Ltd, Shanghai, China
⨯
Jianglin Fan,

Affiliation Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
⨯
Zhe Ren ,

* E-mail: rz62@163.com (ZR); twang-yf@163.com (YFW)

Affiliation Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, Guangdong, China
⨯
Yifei Wang

* E-mail: rz62@163.com (ZR); twang-yf@163.com (YFW)

Affiliation Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, Guangdong, China
⨯

Silencing Herpes Simplex Virus Type 1 Capsid Protein Encoding Genes by siRNA: A Promising Antiviral Therapeutic Approach

Fujun Jin,
Shen Li,
Kai Zheng,
Cuiqin Zhuo,
Kaiqi Ma,
Maoyun Chen,
Qiaoli Wang,
Peizhuo Zhang,
Jianglin Fan,
Zhe Ren

Published: May 2, 2014
https://doi.org/10.1371/journal.pone.0096623

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Viral packaging
Is the Subject Area "Viral packaging" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Herpes simplex virus-1
Is the Subject Area "Herpes simplex virus-1" applicable to this article?

Thanks for your feedback.
Vero cells
Is the Subject Area "Vero cells" applicable to this article?

Thanks for your feedback.
Viral gene expression
Is the Subject Area "Viral gene expression" applicable to this article?

Thanks for your feedback.
Viral genome
Is the Subject Area "Viral genome" applicable to this article?

Thanks for your feedback.
Virions
Is the Subject Area "Virions" applicable to this article?

Thanks for your feedback.