Striatal Neurodevelopment Is Dysregulated in Purine Metabolism Deficiency and Impacts DARPP-32, BDNF/TrkB Expression and Signaling: New Insights on the Molecular and Cellular Basis of Lesch-Nyhan Syndrome

Open Access

Peer-reviewed

Research Article

Ghiabe-Henri Guibinga ,

* E-mail: gguibinga@ucsd.edu

Affiliation Department of Pediatrics, Division of Genetics/Rady Children’s Hospital, University of California San Diego School of Medicine, La Jolla, California, United States of America
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Nikki Barron,

Current address: Sanford-Burnham Institute for Medical Research, La Jolla, California, United States of America

Affiliation Department of Pediatrics, Division of Genetics/Rady Children’s Hospital, University of California San Diego School of Medicine, La Jolla, California, United States of America
⨯
William Pandori

Affiliation Department of Pediatrics, Division of Genetics/Rady Children’s Hospital, University of California San Diego School of Medicine, La Jolla, California, United States of America
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Gene expression
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Neurological signaling
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Protein expression
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Neurons
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