A Pathogenic Mosaic TP53 Mutation in Two Germ Layers Detected by Next Generation Sequencing

Sam Behjati; Mariana Maschietto; Richard D. Williams; Lucy Side; Mike Hubank; Rebecca West; Katie Pearson; Neil Sebire; Patrick Tarpey; Andrew Futreal; Tony Brooks; Michael R. Stratton; John Anderson

doi:10.1371/journal.pone.0096531

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Open Access

Peer-reviewed

Research Article

A Pathogenic Mosaic TP53 Mutation in Two Germ Layers Detected by Next Generation Sequencing

Sam Behjati ,

Contributed equally to this work with: Sam Behjati, Mariana Maschietto

Affiliations Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom, Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom
⨯
Mariana Maschietto ,

Contributed equally to this work with: Sam Behjati, Mariana Maschietto

Affiliation Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, United Kingdom
⨯
Richard D. Williams,

Affiliation Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, United Kingdom
⨯
Lucy Side,

Affiliation Departments of Clinical Genetics, Great Ormond Street Hospital, London, United Kingdom
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Mike Hubank,

Affiliation Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, United Kingdom
⨯
Rebecca West,

Affiliation Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, United Kingdom
⨯
Katie Pearson,

Affiliation Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, United Kingdom
⨯
Neil Sebire,

Affiliation Departments of Histopathology, Great Ormond Street Hospital, London, United Kingdom
⨯
Patrick Tarpey,

Affiliation Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom
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Andrew Futreal,

Affiliation Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom
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Tony Brooks,

Affiliation Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, United Kingdom
⨯
Michael R. Stratton,

Affiliation Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom
⨯
John Anderson

* E-mail: J.anderson@ucl.ac.uk

Affiliation Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, United Kingdom
⨯

A Pathogenic Mosaic TP53 Mutation in Two Germ Layers Detected by Next Generation Sequencing

Sam Behjati,
Mariana Maschietto,
Richard D. Williams,
Lucy Side,
Mike Hubank,
Rebecca West,
Katie Pearson,
Neil Sebire,
Patrick Tarpey,
Andrew Futreal

Published: May 8, 2014
https://doi.org/10.1371/journal.pone.0096531

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