Immunosuppressive Activity of Daphnetin, One of Coumarin Derivatives, Is Mediated through Suppression of NF-κB and NFAT Signaling Pathways in Mouse T Cells

Bocui Song; Zhenning Wang; Yan Liu; Sisi Xu; Guoren Huang; Ying Xiong; Shuang Zhang; Linli Xu; Xuming Deng; Shuang Guan

doi:10.1371/journal.pone.0096502

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Open Access

Peer-reviewed

Research Article

Immunosuppressive Activity of Daphnetin, One of Coumarin Derivatives, Is Mediated through Suppression of NF-κB and NFAT Signaling Pathways in Mouse T Cells

Bocui Song ,

Contributed equally to this work with: Bocui Song, Zhenning Wang

Affiliation Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China
⨯
Zhenning Wang ,

Contributed equally to this work with: Bocui Song, Zhenning Wang

Affiliation Department of Food Quality and Safety, College of Light Industry Economics and Management, Jilin University, Changchun, People’s Republic of China
⨯
Yan Liu,

Affiliation Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China
⨯
Sisi Xu,

Affiliation Department of Food Quality and Safety, College of Light Industry Economics and Management, Jilin University, Changchun, People’s Republic of China
⨯
Guoren Huang,

Affiliation Department of Food Quality and Safety, College of Light Industry Economics and Management, Jilin University, Changchun, People’s Republic of China
⨯
Ying Xiong,

Affiliation Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China
⨯
Shuang Zhang,

Affiliation Department of Food Quality and Safety, College of Light Industry Economics and Management, Jilin University, Changchun, People’s Republic of China
⨯
Linli Xu,

Affiliation Department of Food Quality and Safety, College of Light Industry Economics and Management, Jilin University, Changchun, People’s Republic of China
⨯
Xuming Deng ,

* E-mail: xumingdeng@126.com (XD); gshuang1973@126.com (SG)

Affiliation Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China
⨯
Shuang Guan

* E-mail: xumingdeng@126.com (XD); gshuang1973@126.com (SG)

Affiliations Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China, Department of Food Quality and Safety, College of Light Industry Economics and Management, Jilin University, Changchun, People’s Republic of China
⨯

Immunosuppressive Activity of Daphnetin, One of Coumarin Derivatives, Is Mediated through Suppression of NF-κB and NFAT Signaling Pathways in Mouse T Cells

Bocui Song,
Zhenning Wang,
Yan Liu,
Sisi Xu,
Guoren Huang,
Ying Xiong,
Shuang Zhang,
Linli Xu,
Xuming Deng,
Shuang Guan

Published: May 6, 2014
https://doi.org/10.1371/journal.pone.0096502

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