Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent

• Christine M. Freeman,

  Affiliations Research Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America, Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America

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• Alexandra L. McCubbrey,

  Affiliation Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Sean Crudgington,

  Affiliation Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America

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• Joshua Nelson,

  Affiliation Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America

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• Fernando J. Martinez,

  Affiliation Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America

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• MeiLan K. Han,

  Affiliation Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America

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• George R. Washko Jr,

  Affiliation Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham & Womans Hospital and Harvard University, Boston, Massachusetts, United States of America

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• Stephen W. Chensue,

  Affiliations Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, United States of America, Pathology and Laboratory Medicine Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America, Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan, United States of America

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• Douglas A. Arenberg,

  Affiliation Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America

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• Catherine A. Meldrum,

  Affiliation Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America

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• Lisa McCloskey,

  Affiliation Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America

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• Jeffrey L. Curtis

  * E-mail: jlcurtis@umich.edu

  Affiliations Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America, Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, United States of America, Pulmonary and Critical Care Medicine Section, Medicine Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, United States of America

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