ROS-Mediated Autophagy Induced by Dysregulation of Lipid Metabolism Plays a Protective Role in Colorectal Cancer Cells Treated with Gambogic Acid

Haiyuan Zhang; Yunlong Lei; Ping Yuan; Lingjun Li; Chao Luo; Rui Gao; Jun Tian; Zuohua Feng; Edouard C. Nice; Jun Sun

doi:10.1371/journal.pone.0096418

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Open Access

Peer-reviewed

Research Article

ROS-Mediated Autophagy Induced by Dysregulation of Lipid Metabolism Plays a Protective Role in Colorectal Cancer Cells Treated with Gambogic Acid

Haiyuan Zhang,

Affiliation Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of science and Technology, Wuhan, People’s Republic of China
⨯
Yunlong Lei,

Affiliation Department of Biochemistry and Molecular Biology, and Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China
⨯
Ping Yuan,

Affiliation Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of science and Technology, Wuhan, People’s Republic of China
⨯
Lingjun Li,

Affiliation Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of science and Technology, Wuhan, People’s Republic of China
⨯
Chao Luo,

Affiliation Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of science and Technology, Wuhan, People’s Republic of China
⨯
Rui Gao,

Affiliation Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of science and Technology, Wuhan, People’s Republic of China
⨯
Jun Tian,

Affiliation Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of science and Technology, Wuhan, People’s Republic of China
⨯
Zuohua Feng,

Affiliation Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of science and Technology, Wuhan, People’s Republic of China
⨯
Edouard C. Nice,

Affiliation Monash University, Department of Biochemistry and Molecular Biology, Clayton, Victoria, Australia
⨯
Jun Sun

* E-mail: sun_jun99@163.com

Affiliation Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of science and Technology, Wuhan, People’s Republic of China
⨯

ROS-Mediated Autophagy Induced by Dysregulation of Lipid Metabolism Plays a Protective Role in Colorectal Cancer Cells Treated with Gambogic Acid

Haiyuan Zhang,
Yunlong Lei,
Ping Yuan,
Lingjun Li,
Chao Luo,
Rui Gao,
Jun Tian,
Zuohua Feng,
Edouard C. Nice,
Jun Sun

Published: May 8, 2014
https://doi.org/10.1371/journal.pone.0096418

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