The Complex Interplay between ERK1/2, TGFβ/Smad, and Jagged/Notch Signaling Pathways in the Regulation of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Cells

Open Access

Peer-reviewed

Research Article

Xiaoyun Chen ,

Contributed equally to this work with: Xiaoyun Chen, Wei Xiao

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
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Wei Xiao ,

Contributed equally to this work with: Xiaoyun Chen, Wei Xiao

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
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Wencong Wang,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
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Lixia Luo,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
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Shaobi Ye,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
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Yizhi Liu

* E-mail: yizhi_liu@aliyun.com.

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
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Notch signaling
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SMAD signaling
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Phosphorylation
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Signal inhibition
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ERK signaling cascade
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Cellular crosstalk
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Gene expression
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Retinal detachment
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