Opposing Effects of PI3K/Akt and Smad-Dependent Signaling Pathways in NAG-1-Induced Glioblastoma Cell Apoptosis

Zhiguo Zhang; Lin Wu; Julei Wang; Gang Li; Dayun Feng; Bin Zhang; Lihong Li; Jiandong Yang; Lianting Ma; Huaizhou Qin

doi:10.1371/journal.pone.0096283

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Open Access

Peer-reviewed

Research Article

Opposing Effects of PI3K/Akt and Smad-Dependent Signaling Pathways in NAG-1-Induced Glioblastoma Cell Apoptosis

Zhiguo Zhang ,

Contributed equally to this work with: Zhiguo Zhang, Lin Wu, Julei Wang, Gang Li

Affiliations Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China, Postdoctoral research station of Neurosurgery, Wuhan General Hospital of Guangzhou Command, PLA, Wuhan, China
⨯
Lin Wu ,

Contributed equally to this work with: Zhiguo Zhang, Lin Wu, Julei Wang, Gang Li

Affiliation Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi’an, China
⨯
Julei Wang ,

Contributed equally to this work with: Zhiguo Zhang, Lin Wu, Julei Wang, Gang Li

Affiliation Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China
⨯
Gang Li ,

Contributed equally to this work with: Zhiguo Zhang, Lin Wu, Julei Wang, Gang Li

Affiliation Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China
⨯
Dayun Feng,

Affiliation Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China
⨯
Bin Zhang,

Affiliation Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China
⨯
Lihong Li,

Affiliation Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China
⨯
Jiandong Yang,

Affiliation Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
⨯
Lianting Ma,

Affiliation Postdoctoral research station of Neurosurgery, Wuhan General Hospital of Guangzhou Command, PLA, Wuhan, China
⨯
Huaizhou Qin

* E-mail: qinhuaizhou@hotmail.com

Affiliation Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China
⨯

Opposing Effects of PI3K/Akt and Smad-Dependent Signaling Pathways in NAG-1-Induced Glioblastoma Cell Apoptosis

Zhiguo Zhang,
Lin Wu,
Julei Wang,
Gang Li,
Dayun Feng,
Bin Zhang,
Lihong Li,
Jiandong Yang,
Lianting Ma,
Huaizhou Qin

Published: April 23, 2014
https://doi.org/10.1371/journal.pone.0096283

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