Loss of Function of TET2 Cooperates with Constitutively Active KIT in Murine and Human Models of Mastocytosis

Serena De Vita; Rebekka K. Schneider; Michael Garcia; Jenna Wood; Mathilde Gavillet; Benjamin L. Ebert; Alexander Gerbaulet; Axel Roers; Ross L. Levine; Ann Mullally; David A. Williams

doi:10.1371/journal.pone.0096209

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Peer-reviewed

Research Article

Loss of Function of TET2 Cooperates with Constitutively Active KIT in Murine and Human Models of Mastocytosis

Serena De Vita,

Affiliation Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Rebekka K. Schneider,

Affiliation Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Michael Garcia,

Affiliation Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jenna Wood,

Affiliation Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Mathilde Gavillet,

Affiliation Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Benjamin L. Ebert,

Affiliation Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Alexander Gerbaulet,

Affiliation Institute for Immunology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
⨯
Axel Roers,

Affiliation Institute for Immunology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
⨯
Ross L. Levine,

Affiliation Human Oncology and Pathogenesis Program, and Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Ann Mullally,

Affiliation Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
David A. Williams

* E-mail: DAWilliams@childrens.harvard.edu

Affiliation Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Loss of Function of TET2 Cooperates with Constitutively Active KIT in Murine and Human Models of Mastocytosis

Serena De Vita,
Rebekka K. Schneider,
Michael Garcia,
Jenna Wood,
Mathilde Gavillet,
Benjamin L. Ebert,
Alexander Gerbaulet,
Axel Roers,
Ross L. Levine,
Ann Mullally

Published: May 2, 2014
https://doi.org/10.1371/journal.pone.0096209

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