Transcriptome Profiling of Human Ulcerative Colitis Mucosa Reveals Altered Expression of Pathways Enriched in Genetic Susceptibility Loci

Christopher J. Cardinale; Zhi Wei; Jin Li; Junfei Zhu; Mengnan Gu; Robert N. Baldassano; Struan F. A. Grant; Hakon Hakonarson

doi:10.1371/journal.pone.0096153

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Peer-reviewed

Research Article

Transcriptome Profiling of Human Ulcerative Colitis Mucosa Reveals Altered Expression of Pathways Enriched in Genetic Susceptibility Loci

Christopher J. Cardinale ,

Contributed equally to this work with: Christopher J. Cardinale, Zhi Wei

Affiliation Center for Applied Genomics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Zhi Wei ,

Contributed equally to this work with: Christopher J. Cardinale, Zhi Wei

Affiliation Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America
⨯
Jin Li,

Affiliation Center for Applied Genomics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Junfei Zhu,

Affiliation Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America
⨯
Mengnan Gu,

Affiliation Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America
⨯
Robert N. Baldassano,

Affiliations Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Struan F. A. Grant,

Affiliations Center for Applied Genomics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Hakon Hakonarson

* E-mail: hakonarson@chop.edu

Affiliations Center for Applied Genomics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Transcriptome Profiling of Human Ulcerative Colitis Mucosa Reveals Altered Expression of Pathways Enriched in Genetic Susceptibility Loci

Christopher J. Cardinale,
Zhi Wei,
Jin Li,
Junfei Zhu,
Mengnan Gu,
Robert N. Baldassano,
Struan F. A. Grant,
Hakon Hakonarson

Published: May 1, 2014
https://doi.org/10.1371/journal.pone.0096153

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Gene expression
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Genome-wide association studies
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Ulcerative colitis
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Immune receptor signaling
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Biopsy
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