Delayed Administration of a Bio-Engineered Zinc-Finger VEGF-A Gene Therapy Is Neuroprotective and Attenuates Allodynia Following Traumatic Spinal Cord Injury

Sarah A. Figley; Yang Liu; Spyridon K. Karadimas; Kajana Satkunendrarajah; Peter Fettes; S. Kaye Spratt; Gary Lee; Dale Ando; Richard Surosky; Martin Giedlin; Michael G. Fehlings

doi:10.1371/journal.pone.0096137

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Open Access

Peer-reviewed

Research Article

Delayed Administration of a Bio-Engineered Zinc-Finger VEGF-A Gene Therapy Is Neuroprotective and Attenuates Allodynia Following Traumatic Spinal Cord Injury

Sarah A. Figley,

Affiliations Department of Genetics and Development, Toronto Western Research Institute, and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
⨯
Yang Liu,

Affiliation Department of Genetics and Development, Toronto Western Research Institute, and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada
⨯
Spyridon K. Karadimas,

Affiliations Department of Genetics and Development, Toronto Western Research Institute, and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
⨯
Kajana Satkunendrarajah,

Affiliation Department of Genetics and Development, Toronto Western Research Institute, and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada
⨯
Peter Fettes,

Affiliation Department of Genetics and Development, Toronto Western Research Institute, and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada
⨯
S. Kaye Spratt,

Affiliation Department of Therapeutic Development, Sangamo BioSciences, Pt. Richmond, California, United States of America
⨯
Gary Lee,

Affiliation Department of Therapeutic Development, Sangamo BioSciences, Pt. Richmond, California, United States of America
⨯
Dale Ando,

Affiliation Department of Therapeutic Development, Sangamo BioSciences, Pt. Richmond, California, United States of America
⨯
Richard Surosky,

Affiliation Department of Therapeutic Development, Sangamo BioSciences, Pt. Richmond, California, United States of America
⨯
Martin Giedlin,

Affiliation Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
⨯
Michael G. Fehlings

* E-mail: michael.fehlings@uhn.on.ca

Affiliations Department of Genetics and Development, Toronto Western Research Institute, and Spinal Program, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
⨯

Delayed Administration of a Bio-Engineered Zinc-Finger VEGF-A Gene Therapy Is Neuroprotective and Attenuates Allodynia Following Traumatic Spinal Cord Injury

Sarah A. Figley,
Yang Liu,
Spyridon K. Karadimas,
Kajana Satkunendrarajah,
Peter Fettes,
S. Kaye Spratt,
Gary Lee,
Dale Ando,
Richard Surosky,
Martin Giedlin

Published: May 20, 2014
https://doi.org/10.1371/journal.pone.0096137

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Spinal cord injury
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Central nervous system
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Spinal cord
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Allodynia
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Angiogenesis
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Apoptosis
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Endothelial cells
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