Rat Experimental Model of Myocardial Ischemia/Reperfusion Injury: An Ethical Approach to Set up the Analgesic Management of Acute Post-Surgical Pain

• Maria Chiara Ciuffreda,

  Affiliations Department of Cardiothoracic and Vascular Sciences – Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, Fondazione IRCCS (IRCCS: Institute for Treatment and Research) Policlinico San Matteo, Pavia, Italy, Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

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• Valerio Tolva,

  Affiliation Surgical Department, IRCCS Istituto Auxologico Italiano, Milan, Italy

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• Renato Casana,

  Affiliation Surgical Department, IRCCS Istituto Auxologico Italiano, Milan, Italy

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• Massimiliano Gnecchi,

  Affiliations Department of Cardiothoracic and Vascular Sciences – Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, Fondazione IRCCS (IRCCS: Institute for Treatment and Research) Policlinico San Matteo, Pavia, Italy, Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy, Department of Medicine, Cape Town University, Cape Town, South Africa

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• Emilio Vanoli,

  Affiliation Department of Cardiology, IRCCS Multimedica, Sesto San Giovanni, Milan, Italy

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• Carla Spazzolini,

  Affiliation Center for Cardiac Arrhythmias of Genetic Base, IRCCS Istituto Auxologico Italiano, Milan, Italy

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• John Roughan,

  Affiliation Institute of Neuroscience, Comparative Biology Centre, University of Newcastle, Newcastle upon Tyne, United Kingdom

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• Laura Calvillo

  * E-mail: l.calvillo@auxologico.it

  Affiliation Laboratory of Cardiac Arrhythmias of Genetic Base, IRCCS Istituto Auxologico Italiano, Milan, Italy

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