Specific Activation of K-RasG12D Allele in the Bladder Urothelium Results in Lung Alveolar and Vascular Defects

Open Access

Peer-reviewed

Research Article

Specific Activation of K-Ras^G12D Allele in the Bladder Urothelium Results in Lung Alveolar and Vascular Defects

Francisco Ayala de la Peña ,

Contributed equally to this work with: Francisco Ayala de la Peña, Keizo Kanasaki

Affiliation Division of Matrix Biology/Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
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Keizo Kanasaki ,

Contributed equally to this work with: Francisco Ayala de la Peña, Keizo Kanasaki

Affiliation Division of Matrix Biology/Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
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Megumi Kanasaki,

Affiliation Division of Matrix Biology/Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
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Sylvia Vong,

Affiliation Division of Matrix Biology/Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
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Carlota Rovira,

Affiliation Department of Pathology, Hospital Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain
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Raghu Kalluri

* E-mail: rkalluri@mdanderson.org

Affiliation Department of Cancer Biology, Metastasis Research Center, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
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Lung development
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Mouse models
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Urothelium
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Bladder
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Genetically modified animals
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Amniotic fluid
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Lung and intrathoracic tumors
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Morphogenesis
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