Semapimod Sensitizes Glioblastoma Tumors to Ionizing Radiation by Targeting Microglia

Ian S. Miller; Sebastien Didier; David W. Murray; Tia H. Turner; Magimairajan Issaivanan; Rosamaria Ruggieri; Yousef Al-Abed; Marc Symons

doi:10.1371/journal.pone.0095885

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Peer-reviewed

Research Article

Semapimod Sensitizes Glioblastoma Tumors to Ionizing Radiation by Targeting Microglia

Ian S. Miller,

Current address: I. Miller and D. Murray: Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

Affiliation Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York, United States of America
⨯
Sebastien Didier,

Affiliation Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York, United States of America
⨯
David W. Murray,

Current address: I. Miller and D. Murray: Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

Affiliation Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York, United States of America
⨯
Tia H. Turner,

Affiliation Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York, United States of America
⨯
Magimairajan Issaivanan,

Current address: Pediatric Neuro-Oncology, Cancer Care Manitoba, Winnipeg, Manitoba, Canada

Affiliation Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York, United States of America
⨯
Rosamaria Ruggieri,

Affiliation Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York, United States of America
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Yousef Al-Abed,

Affiliation Center for Molecular Innovation, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York, United States of America
⨯
Marc Symons

* E-mail: msymons@nshs.edu

Affiliation Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York, United States of America
⨯

Semapimod Sensitizes Glioblastoma Tumors to Ionizing Radiation by Targeting Microglia

Ian S. Miller,
Sebastien Didier,
David W. Murray,
Tia H. Turner,
Magimairajan Issaivanan,
Rosamaria Ruggieri,
Yousef Al-Abed,
Marc Symons

Published: May 9, 2014
https://doi.org/10.1371/journal.pone.0095885

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Microglial cells
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Glioblastoma cells
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Malignant tumors
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Cancers and neoplasms
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Glioblastoma multiforme
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Cancer treatment
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Radiation therapy
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Ionizing radiation
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