Generation and Characterization of a Mouse Model Harboring the Exon-3 Deletion in the Cardiac Ryanodine Receptor

Yingjie Liu; Ruiwu Wang; Bo Sun; Tao Mi; Jingqun Zhang; Yongxin Mu; Ju Chen; Michael J. Bround; James D. Johnson; Anne M. Gillis; S. R. Wayne Chen

doi:10.1371/journal.pone.0095615

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Open Access

Peer-reviewed

Research Article

Generation and Characterization of a Mouse Model Harboring the Exon-3 Deletion in the Cardiac Ryanodine Receptor

Yingjie Liu,

Affiliation Libin Cardiovascular Institute of Alberta, Departments of Physiology & Pharmacology, and Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯
Ruiwu Wang,

Affiliation Libin Cardiovascular Institute of Alberta, Departments of Physiology & Pharmacology, and Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯
Bo Sun,

Affiliation Libin Cardiovascular Institute of Alberta, Departments of Physiology & Pharmacology, and Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯
Tao Mi,

Current address: Department of Geriatrics of Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China

Affiliation Libin Cardiovascular Institute of Alberta, Departments of Physiology & Pharmacology, and Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯
Jingqun Zhang,

Current address: Department of Cardiology of Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China

Affiliation Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Yongxin Mu,

Affiliation Department of Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Ju Chen,

Affiliation Department of Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Michael J. Bround,

Affiliation Cardiovascular Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯
James D. Johnson,

Affiliation Cardiovascular Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Anne M. Gillis,

Affiliation Libin Cardiovascular Institute of Alberta, Departments of Physiology & Pharmacology, and Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯
S. R. Wayne Chen

* E-mail: swchen@ucalgary.ca

Affiliations Libin Cardiovascular Institute of Alberta, Departments of Physiology & Pharmacology, and Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯

Generation and Characterization of a Mouse Model Harboring the Exon-3 Deletion in the Cardiac Ryanodine Receptor

Yingjie Liu,
Ruiwu Wang,
Bo Sun,
Tao Mi,
Jingqun Zhang,
Yongxin Mu,
Ju Chen,
Michael J. Bround,
James D. Johnson,
Anne M. Gillis

Published: April 17, 2014
https://doi.org/10.1371/journal.pone.0095615

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