Heterologous Prime-Boost Vaccination with MF59-Adjuvanted H5 Vaccines Promotes Antibody Affinity Maturation towards the Hemagglutinin HA1 Domain and Broad H5N1 Cross-Clade Neutralization

• Surender Khurana ,

  * E-mail: surender.khurana@fda.hhs.gov (SK); hana.golding@fda.hhs.gov (HG)

  Affiliation Division of Viral products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America

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• Elizabeth M. Coyle,

  Affiliation Division of Viral products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America

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• Milena Dimitrova,

  Affiliation Division of Viral products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America

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• Flora Castellino,

  Affiliation Novartis Vaccines and Diagnostics Srl, Sienna, Italy

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• Karl Nicholson,

  Affiliation Department of Infection, Inflammation, and Immunity, Maurice Shock Medical Sciences Building, University of Leicester, Leicester, United Kingdom

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• Giuseppe Del Giudice,

  Affiliation Novartis Vaccines and Diagnostics Srl, Sienna, Italy

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• Hana Golding

  * E-mail: surender.khurana@fda.hhs.gov (SK); hana.golding@fda.hhs.gov (HG)

  Affiliation Division of Viral products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America

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