Increased SOX2 Gene Copy Number Is Associated with FGFR1 and PIK3CA Gene Gain in Non-Small Cell Lung Cancer and Predicts Improved Survival in Early Stage Disease

Luca Toschi; Giovanna Finocchiaro; Teresa T. Nguyen; Margaret C. Skokan; Laura Giordano; Letizia Gianoncelli; Matteo Perrino; Licia Siracusano; Luca Di Tommaso; Maurizio Infante; Marco Alloisio; Massimo Roncalli; Marta Scorsetti; Pasi A. Jänne; Armando Santoro; Marileila Varella-Garcia

doi:10.1371/journal.pone.0095303

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Peer-reviewed

Research Article

Increased SOX2 Gene Copy Number Is Associated with FGFR1 and PIK3CA Gene Gain in Non-Small Cell Lung Cancer and Predicts Improved Survival in Early Stage Disease

Luca Toschi ,

* E-mail: luca.toschi@cancercenter.humanitas.it

Affiliation Division of Oncology and Hematology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
⨯
Giovanna Finocchiaro,

Affiliation Division of Oncology and Hematology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
⨯
Teresa T. Nguyen,

Affiliation University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Margaret C. Skokan,

Affiliation Forensic Biology/DNA, Denver Police Department Crime Laboratory, Denver, Colorado, United States of America
⨯
Laura Giordano,

Affiliation Biostatistics Unit, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
⨯
Letizia Gianoncelli,

Affiliation Division of Oncology and Hematology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
⨯
Matteo Perrino,

Affiliation Division of Oncology and Hematology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
⨯
Licia Siracusano,

Affiliation Division of Oncology and Hematology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
⨯
Luca Di Tommaso,

Affiliations Division of Pathology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy, University of Milan, Milan, Italy
⨯
Maurizio Infante,

Affiliation Division of Thoracic Surgery, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
⨯
Marco Alloisio,

Affiliation Division of Thoracic Surgery, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
⨯
Massimo Roncalli,

Affiliations Division of Pathology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy, University of Milan, Milan, Italy
⨯
Marta Scorsetti,

Affiliation Department of Radiotherapy, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
⨯
Pasi A. Jänne,

Affiliation Lowe Center for Thoracic Oncology and Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Armando Santoro,

Affiliation Division of Oncology and Hematology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
⨯
[ ... ],
Marileila Varella-Garcia

Affiliation University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
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Increased SOX2 Gene Copy Number Is Associated with FGFR1 and PIK3CA Gene Gain in Non-Small Cell Lung Cancer and Predicts Improved Survival in Early Stage Disease

Luca Toschi,
Giovanna Finocchiaro,
Teresa T. Nguyen,
Margaret C. Skokan,
Laura Giordano,
Letizia Gianoncelli,
Matteo Perrino,
Licia Siracusano,
Luca Di Tommaso,
Maurizio Infante

Published: April 15, 2014
https://doi.org/10.1371/journal.pone.0095303

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Non-small cell lung cancer
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Histology
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Gene amplification
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